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Abstract #2792

Effects of Temporal Resolution on Quantitative DCE-MRI Prediction of Breast Cancer Therapy Response

Wei Huang1, Aneela Afzal1, Alina Tudorica1, Yiyi Chen1, Stephen Y-C Chui1, Arpana Naik1, Megan Troxell1, Kathleen Kemmer1, Karen Y Oh1, Nicole Roy1, Megan L Holtorf1, and Xin Li1

1Oregon Health & Science University, Portland, OR, United States

15 breast cancer patients undergoing neoadjuvant chemotherapy (NACT) consented to two DCE-MRI studies at the same time points before, during, and after NACT: one with high temporal resolution (tRes) and the other with low tRes. There were systematic errors in estimated pharmacokinetic (PK) parameters from the low tRes data compared to the high tRes data. However, the abilities of PK parameters for early prediction of pathologic response to NACT were not affected by poorer tRes.

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