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Abstract #2793

Effect of Neoadjuvant Chemotherapy on in-vivo MRS determined tCho and Membranous and Cytoplasmic b-catenin Expression in Breast Cancer Patients

Naranamangalam R Jagannathan1, Khushbu Agarwal1, Uma Sharma1, Sandeep Mathur2, Vurthaluru Seenu3, and Rajinder Parshad3

1Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Pathology, All India Institute of Medical Sciences, New Delhi, India, 3Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India

We evaluated the changes in tCho levels and β-catenin expression (membrane and cytoplasm) after III neoadjuvant chemotherapy in breast cancer patients. Significant reduction in β-catenin expression (membranous and cytoplasmic) was observed after therapy. Post-therapy, tCho reduced significantly in tumors with Grades 1 and 2 membranous β-catenin expression and also in tumors with IRS 0 and Grade 1 cytoplasmic β-catenin. Prior to therapy, tCho was positively associated with cytoplasmic β-catenin while negatively with membranous protein. However post-therapy tCho was negatively associated with both cytoplasmic and membranous β-catenin. This signifies antiproliferative and apoptosis induction effects of chemotherapy drugs on breast cancer patients.

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