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Abstract #2804

Chemical exchange saturation transfer (CEST) and relaxometry as biomarkers for assessing response of brain metastases to stereotactic radiosurgery

Hatef Mehrabian1,2, Kimberly L Desmond3, Anne L Martel1,2, Arjun Sahgal1,4, Hany Soliman1,4, and Greg J Stanisz1,2

1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, Canada, 4Radiation Oncology, Odette Cancer Centre, Toronto, ON, Canada

Quantitative MRI techniques that probe the metabolic and micro-structural changes in the tumor have the potential to assess response of brain metastases to stereotactic radiosurgery early after treatment. Two techniques were investigated here: a) Chemical Exchange Saturation Transfer (CEST), b) Relaxometry.

Among all model parameters, early changes in the intracellular-extracellular water exchange rate in relaxometry, and peak amplitude of nuclear overhauser effect at the ipsilateral normal appearing white matter in CEST provided the strongest correlation with tumor volume change one-month post-treatment. We also demonstrated that these two parameters were highly correlated suggesting they could provide complementary information about treatment effects.

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