Gigin Lin1, Yu-Chun Lin1, Hsi-Mu Chen 1, and Chiun-Chieh Wang2
1Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 2Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
The
intracellular storage and utilization of lipids are critical for cancer cells
to maintain energy homeostasis. In this study, we investigated the changes of
lipid metabolites in murine TRAMP-C prostate cancer cells and tumors following radiotherapy.
The lipid profile following radiotherapy demonstrated increased levels of fatty
acids and triacylglycerols,
before the change of tumor size. The increase of lipids signals can potentially
serve as early response biomakers in clinical setting for prostate cancer
patients following radiotherapy.
