Abstract #2806

Altered lipid metabolism on 1H NMR as response biomarkers in prostate cancer cells and tumors following radiotherapy

Gigin Lin¹, Yu-Chun Lin¹, Hsi-Mu Chen ¹, and Chiun-Chieh Wang²

¹Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

The intracellular storage and utilization of lipids are critical for cancer cells to maintain energy homeostasis. In this study, we investigated the changes of lipid metabolites in murine TRAMP-C prostate cancer cells and tumors following radiotherapy. The lipid profile following radiotherapy demonstrated increased levels of fatty acids and triacylglycerols, before the change of tumor size. The increase of lipids signals can potentially serve as early response biomakers in clinical setting for prostate cancer patients following radiotherapy.

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