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Abstract #2807

Impact of T1 and B1 correction on quantitative DCE-MRI for assessing longitudinal therapy response in breast cancer

Dattesh D Shanbhag1, Parita Sanghani1, Reem Bedair 2, Venkata Veerendranadh Chebrolu1, Sandeep N Gupta3, Scott Reid 4, Fiona Gilbert 2, Andrew Patterson 2, Rakesh Mullick1, and Martin Graves2

1GE Global Research, Bangalore, India, 2University of Cambridge, Cambridge, United Kingdom, 3GE Global Research, Niskayuna, NY, United States, 4GE Healthcare, Leeds, United Kingdom

In this work, we investigated the impact of incorporating T1 and/or B1 maps on PK parameters in breast cancer patients and impact of these PK maps on assessing therapy response in longitudinal data. DCE-MRI PK parameters in six breast cancer patients was investigated with four different processing schemes comprising combinations of T1 and B1 map with DCE and its trend assessed in longitudinal data . We demonstrate that in breast tumor imaging, a DCE protocol incorporating T1 and B1 mapping can be more reliable in reflecting tumor heterogeneity and predicting therapy response longitudinally.­­

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