Abstract #2807

Impact of T1 and B1 correction on quantitative DCE-MRI for assessing longitudinal therapy response in breast cancer

Dattesh D Shanbhag¹, Parita Sanghani¹, Reem Bedair ², Venkata Veerendranadh Chebrolu¹, Sandeep N Gupta³, Scott Reid ⁴, Fiona Gilbert ², Andrew Patterson ², Rakesh Mullick¹, and Martin Graves²

¹GE Global Research, Bangalore, India, ²University of Cambridge, Cambridge, United Kingdom, ³GE Global Research, Niskayuna, NY, United States, ⁴GE Healthcare, Leeds, United Kingdom

In this work, we investigated the impact of incorporating T₁and/or B₁ maps on PK parameters in breast cancer patients and impact of these PK maps on assessing therapy response in longitudinal data. DCE-MRI PK parameters in six breast cancer patients was investigated with four different processing schemes comprising combinations of T₁ and B₁ map with DCE and its trend assessed in longitudinal data . We demonstrate that in breast tumor imaging, a DCE protocol incorporating T₁ and B₁ mapping can be more reliable in reflecting tumor heterogeneity and predicting therapy response longitudinally.

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