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Abstract #2808

Monitoring Breast Cancer Response to Neoadjuvant Chemotherapy by Diffusion Tensor Imaging

Edna Furman-Haran1, Noam Nissan2, Hadassa Degani2, and Julia Camps Herrero3

1Department of Biological Services, The Weizmann Institute of Science, Rehovot, Israel, 2Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel, 3Radiology, Hospital de la Ribera, Alzira, Spain

We have evaluated the ability of diffusion tensor imaging (DTI) to assess breast cancer response to neoadjuvant chemotherapy. Changes in lesion size and diffusion parameters in response to therapy were determined. Diameter and volume measurement derived from DTI were compared to those derived from dynamic contrast enhanced (DCE) MRI and to post surgery pathological reports. A high congruence was found between DTI and DCE-MRI for tumor size and response evaluation, with both methods showing a good agreement with pathology results.

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