Abstract #2813

Oscillatory shear strain impacts metastatic cancer cell spread

Marlies Christina Hoelzl¹, Marco Fiorito², Ondrej Holub³, Gilbert Fruhwirth⁴, and Ralph Sinkus¹

¹Biomedical Engineering, King's College London, London, United Kingdom, ²Imaging Chemistry and Biology, King's College London, London, United Kingdom, ³London, United Kingdom, ⁴Imaging Chemistry and Biology, King's College London, Lodnon, United Kingdom

Major reasons of cancer related deaths are repercussion of the dissemination of cancer cells from the primary tumour site and an outgrowth at the secondary metastatic site. The microenvironment where the cancer cells reside with various signals, are central factors to provide cancer cell spread throughout the body; signals can be (bio)chemical or mechanical nature. Translation of mechanical forces, displacements and deformations into biochemical signals (i.e. mechanotransduction) affects their adhesion, spread and survival. We show here, that focussed shear waves operating at specific frequency and amplitude affects the metastatic behaviour of cancer cells by reducing the invasive behaviour and growth.

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