Abstract #2814

Can Diffusion Weighted MRI Assess Early Response of Lymphadenopathy to Induction Chemotherapy in Nasopharyngeal Cancer: A Heterogeneity Analysis Approach

Manijeh Beigi¹, Anahita Fathi Kazerooni¹, Mojtaba Safari², Marzieh Alamolhoda³, Ahmad Ameri⁴, Shiva Moghadam⁵, Mohsen Shojaee Moghadam⁶, and Hamidreza SalighehRad²

¹, Tehran University of Medical Sciences, Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Institute for Advanced Medical Imaging, Tehran, Iran, ²Tehran University of Medical Sciences, Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Institute for Advanced Medical Imaging, Tehran, Iran, ³Statistics, Shiraz University of Medical Science, Shiraz, Iran, ⁴Jorjani Radiotherapy Center, Shahid Beheshti of Medical Sciense, Tehran, Iran, ⁵Shahid Beheshti University of Medical Science, Tehran, Iran, ⁶Payambaran MRI center, Tehran, Iran

Induction chemotherapy is an effective way to control subclinical metastasis in locally-advanced nasopharyngeal cancer patients. Diffusion-weighted MRI is a noninvasive imaging technique allowing some degree of tissue characterization by showing and quantifying molecular diffusion. Histogram analysis on ADC map could be carried out to reveal physiological alterations early after IC. For this purpose, several quantitative metrics from ADC-map were explored to obtain the most accurate feature(s) as potential predictive biomarker for early response of the lymphnode to IC. If the outcome can be predicted at an early stage of the treatment, the patient could be spared from unnecessary treatment toxicity.

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