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Abstract #2816

trueFLASH: Model-Based Iterative T1 Mapping using Variable-Flip-Angle Fast Low-Angle Shot

Tom Hilbert1,2,3, Damien Nguyen4,5, Jean-Philippe Thiran2,3, Gunnar Krueger2,3,6, Tobias Kober1,2,3, and Oliver Bieri4,5

1Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 5Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 6Siemens Medical Solutions USA, Inc., Boston, MA, United States

Various methods have been published to quantify the longitudinal relaxation T1; amongst others, a variable-flip-angle fast low-angle shot acquisition can be used. Here, we suggest applying an 8-fold undersampling to such an acquisition, subsequently using a model-based iterative optimization to estimate T1 maps. This approach allows the acquisition of whole-brain 1.3mm isotropic T1 maps within 3:20min using 16 different flip angles. Aliasing artifacts due to the undersampling were successfully removed by the iterative reconstruction. However, the T1 maps show a slight overestimation of T1 values and require a B1-field correction as it is typical for variable-flip-angle approaches.

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