Abstract #2816

trueFLASH: Model-Based Iterative T1 Mapping using Variable-Flip-Angle Fast Low-Angle Shot

Tom Hilbert^1,2,3, Damien Nguyen^4,5, Jean-Philippe Thiran^2,3, Gunnar Krueger^2,3,6, Tobias Kober^1,2,3, and Oliver Bieri^4,5

¹Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, ⁵Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ⁶Siemens Medical Solutions USA, Inc., Boston, MA, United States

Various methods have been published to quantify the longitudinal relaxation T1; amongst others, a variable-flip-angle fast low-angle shot acquisition can be used. Here, we suggest applying an 8-fold undersampling to such an acquisition, subsequently using a model-based iterative optimization to estimate T1 maps. This approach allows the acquisition of whole-brain 1.3mm isotropic T1 maps within 3:20min using 16 different flip angles. Aliasing artifacts due to the undersampling were successfully removed by the iterative reconstruction. However, the T1 maps show a slight overestimation of T1 values and require a B1-field correction as it is typical for variable-flip-angle approaches.

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