The effect of through-plane gradients on 2D gradient-echo acquisitions: are sinc-term corrections appropriate for R2* mapping?
Mukund Balasubramanian1,2 and Robert V. Mulkern1,2
1Department of Radiology, Boston Children's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States
We made slice profile measurements and acquired 2D multi-gradient-echo data on a phantom in the presence of various through-plane gradients. The sinc-term correction for R2* mapping that is commonly used to compensate for the dephasing effects of these gradients was substantially outperformed by a correction based on the measured slice profiles. Our results highlight the importance of incorporating realistic slice profiles into the estimation of “intrinsic” R2* values, which may contain information about tissue structure at microscopic-to-mesoscopic spatial scales.
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