Abstract #2822

Molecular Mechanism of Transverse Relaxation in Whole Blood with Plasma Contrast Reagent: Simulations of Bulk Magnetic Susceptibility and Water Exchange

Gregory J Wilson¹, Charles S Springer², Sarah Bastawrous^1,3, and Jeffrey H Maki¹

¹University of Washington, Seattle, WA, United States, ²Oregon Health and Science University, Portland, OR, United States, ³Puget Sound VA HCS, Seattle, WA, United States

Previously reported T₂* values in oxygenated whole blood with gadolinium based contrast reagents are very small. This has important implications for optimization of contrast-enhanced MR angiography and quantification of arterial input functions. To investigate the molecular mechanism of these short T₂* values, we have performed Monte Carlo simulations of signal dephasing that predict the reported values remarkably well. Intracellular water signal experiences a frequency shift that is dependent on the orientation of the RBC in the magnetic field. The resulting frequency distribution in combination with trans-membrane water exchange results in rapid dephasing of water signal.

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