Abstract #2834

Paradoxical Narrowing of the Spectroscopy Water Peak in the Presence of Iron Overload

Diego Hernando¹, Samir D Sharma¹, Debra E Horng², and Scott B Reeder^1,2,3,4,5

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

In phantoms with large iron particles, as well as in patients with liver iron overload, a paradoxical relationship was observed where the linewidth measured from MRS was smaller than the linewidth obtained from multi-echo spoiled gradient echo MRI. Assuming a model of “apparent” R2 decay in the presence of iron where single-echo acquisitions are essentially diffusion-weighted by the iron-induced B0 heterogeneities, we speculate that different isochromats within the observed spectra undergo different diffusion weighting related to their location relative to nearby large iron particles. These observations may have implications for the characterization of iron deposition in tissue.

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