Abstract #2833

Quantifying Chemical Exchange Contributions in Mixtures Using Spin-Lock MRI

John Thomas Spear^1,2 and John Gore^1,2,3,4

¹Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Radiology, Vanderbilt University, Nashville, TN, United States, ⁴Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

R_1ρ dispersion provides insight into the rates of molecular processes that give rise to relaxation, and a technique called Exchange Rate Contrast (ERC) can differentiate proton pools based on chemical exchange rates. Double dispersion phenomena may occur when three exchanging proton pools are present, and parametric images may be calculated in which the image intensity scales with the concentration of the exchanging pools. A theoretical equation was derived for this contrast and shown to align well with Bloch-McConnell simulations. Various applications with exogenous contrast agents present a great deal of potential for utilizing this technique in practice.

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