Abstract #2832

Colloidal Nanoparticles for MRI Contrast Agents

Akbar Alipour^1,2,3, Vijay Kumar Shamra^3,4, Zeliha Soran Erdem³, Zaliha Gamze Aykut⁵, and Hilmi Volkan Demir^2,3,4

¹UMRAM-National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey, ²Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey, ³UNAM – Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, Turkey, ⁴School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore, Singapore, ⁵Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

Magnetic resonance imaging (MRI) contrast agents, employed as image contrast enhancement mechanism, are able to change either negative or positive signal intensity. T₂ contrast normally offers magnetic susceptibility artifacts and decreases the resolution. On the other hand, T₁ contrast provides high spatial resolution, but it suffers from the deficiency of high contrast-to-noise ratio, which limits their clinical applications. To overcome the aforementioned limitations, we offer cubic shape super-paramagnetic iron oxide nanoparticles (SPIONs) as dual-mode colloidal MRI contrast agents. The in vitro and in vivo T₁and T₂MR images promise the great potential clinical application of SPIO nanocubes as dual-mode MR contrast agent.

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