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Abstract #2832

Colloidal Nanoparticles for MRI Contrast Agents

Akbar Alipour1,2,3, Vijay Kumar Shamra3,4, Zeliha Soran Erdem3, Zaliha Gamze Aykut5, and Hilmi Volkan Demir2,3,4

1UMRAM-National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey, 2Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey, 3UNAM – Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, Turkey, 4School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore, Singapore, 5Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

Magnetic resonance imaging (MRI) contrast agents, employed as image contrast enhancement mechanism, are able to change either negative or positive signal intensity. T2 contrast normally offers magnetic susceptibility artifacts and decreases the resolution. On the other hand, T1 contrast provides high spatial resolution, but it suffers from the deficiency of high contrast-to-noise ratio, which limits their clinical applications. To overcome the aforementioned limitations, we offer cubic shape super-paramagnetic iron oxide nanoparticles (SPIONs) as dual-mode colloidal MRI contrast agents. The in vitro and in vivo T1 and T2 MR images promise the great potential clinical application of SPIO nanocubes as dual-mode MR contrast agent.

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