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Abstract #2846

Assessing Response to Hyperoxic Respiratory Challenges with Quantitative Susceptibility Mapping in Primary Malignant Brain Tumors

Pinar Senay Özbay1,2, Cristina Rossi1, Sonja Stieb3, Oliver Riesterer3, Andreas Boss1, Klaas Paul Pruessmann2, and Daniel Nanz1

1Department of Radiology, University Hospital Zurich, Zurich, Switzerland, 2Institute of Biomedical Engineering, ETH Zurich, Zurich, Switzerland, 3Department of Radio-Oncology, University Hospital Zürich, Zurich, Switzerland

Glioblastoma multiforme and anaplastic astrocytoma are aggressive brain tumors which can form large heterogeneous lesions, parts of which respond with varying sensitivity to radiotherapy. The long-term goal of the current study is to characterize the oxygenation state of tumors or parts of heterogeneous large tumors by quantitative-susceptibility-mapping, under hyperoxic respiratory challenge, and yield valuable information, e.g., for an improved dose shaping, which may lead to an improved therapy outcome. The preliminary results suggest that QSM may indeed be capable of differentiating the response of well vascularized tumor-tissue volumes to respiratory-induced hypoxia from the response of likely necrotic and edematous volumes.

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