Abstract #2848

How to compare SHARP parameters? New definitions in physical rather than numerical space

Pinar Senay Özbay^1,2, Andreas Deistung³, Xiang Feng^3,4, Daniel Nanz², Jürgen Reichenbach^3,5, and Ferdinand Schweser^4,6

¹Institute of Biomedical Engineering, ETH Zurich, Zurich, Switzerland, ²Department of Radiology, University Hospital Zurich, Zurich, Switzerland, ³Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ⁴Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ⁵Friedrich Schiller University Jena, Michael Stifel Center for Data-driven and Simulation Science Jena, Jena, Germany, ⁶MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

Sophisticated Harmonic Artifact Reduction for Phase data (SHARP) is a method widely used for removal of background fields, which is one of the steps of Quantitative susceptibility mapping (QSM). In this work we analyzed SHARP using different radii between 1 and 15mm, with varying regularization parameters in mm^-1, determined optimum values and showed two cases that can arise due to wrong interpretation of the original parameters. A direct conversion of the old-parameters-scheme to the new one is presented. Best and extreme cases for parameters are demonstrated for simulated models and an in-vivo case, and the effects on images are discussed.

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