Abstract #2850

Susceptibility-driven oscillations in Multi-Gradient-Echo MRI reflect axonal microstructures

Daniel Nunes¹, Tomás Cruz¹, Sune Nørhøj Jespersen², and Noam Shemesh¹

¹Champalimaud Neuroscience Program, Champalimaud Center for the Unknown, Lisbon, Portugal, ²CFIN/MindLab, Aarhus Universitet, Århus C, Denmark

Characterizing white matter (WM) microstructure in terms of axon size and volume fraction remains elusive and typically requires extremely strong gradients to resolve water diffusion in micron-sized axons. Here, we develop and apply a new approach for quantifying WM microstructure using a simple multi-gradient-echo (MGE) sequence. We use rat spinal cord as our experimental system, and show that, at long echo times, oscillations in the signal decay emerge, which can be used to robustly quantify the WM microstructure. The ensuing parameteric maps segment the SC into its underlying microstructures. The simplicity of the approach bodes well for many future applications.

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