Abstract #2851

Magnetic Saturation and Field Dependency on Magnetic Susceptibility of Ferumoxytol

Jean-Christophe Brisset¹, Pippa Storey¹, Saifeng Liu², E. Mark Haacke³, and Yulin Ge¹

¹Radiology, New York University School of Medicine, New York, NY, United States, ²The MRI Institute for Biomedical Research, Waterloo, ON, Canada, ³Radiology, Wayne State University, Detroit, MI, United States

The magnetization of diamagnetic and paramagnetic materials is proportional to the strength of the applied magnetic field, with a constant of proportionality (χ) known as the magnetic susceptibility. While the magnetization of ferromagnetic and superparamagnetic materials is much higher than that of diamagnetic and paramagnetic materials, it becomes saturated in strong magnetic fields. We show that the magnetization of USPIO agents such as Ferumoxytol saturates at around 1.5T. This introduces a perceived inverse correlation between apparent susceptibility and field strength. By contrast, the magnetization of GdDTPA is proportional to field strength up to 7T, as expected for a paramagnetic material.

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