Abstract #2859

Quantification of Liver Iron Concentration using the Apparent Susceptibility of Vessels

Saifeng Liu¹, Chaoyue Wang², Xiaoqi Zhang³, Hongyan Ni³, Panli Zuo⁴, Jiani Hu⁵, and E. Mark Haacke^1,2,5

¹The MRI Institute for Biomedical Research, Waterloo, ON, Canada, ²School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, ³Tianjin First Central Hospital, Tianjin, China, People's Republic of, ⁴Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of, ⁵Department of radiology, Wayne State University, Detroit, MI, United States

Quantification of liver iron concentration (LIC) is critical for the diagnosis of patients with liver iron overload. LIC is conventionally measured using R₂/R₂* mapping methods which have limited accuracy and precision, partly due to the non-linear relation between relaxation rate and iron concentration. Quantitative susceptibility mapping (QSM) has been shown to be effective in quantifying cerebral iron deposition. For LIC quantification using QSM, the challenges include dealing with air-tissue interface in the abdomen in background field removal and solving the ill-posed inverse problem. Here we show a method which uses the apparent susceptibility of liver vessels for LIC quantification.

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