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Abstract #2859

Quantification of Liver Iron Concentration using the Apparent Susceptibility of Vessels

Saifeng Liu1, Chaoyue Wang2, Xiaoqi Zhang3, Hongyan Ni3, Panli Zuo4, Jiani Hu5, and E. Mark Haacke1,2,5

1The MRI Institute for Biomedical Research, Waterloo, ON, Canada, 2School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 3Tianjin First Central Hospital, Tianjin, China, People's Republic of, 4Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of, 5Department of radiology, Wayne State University, Detroit, MI, United States

Quantification of liver iron concentration (LIC) is critical for the diagnosis of patients with liver iron overload. LIC is conventionally measured using R2/R2* mapping methods which have limited accuracy and precision, partly due to the non-linear relation between relaxation rate and iron concentration. Quantitative susceptibility mapping (QSM) has been shown to be effective in quantifying cerebral iron deposition. For LIC quantification using QSM, the challenges include dealing with air-tissue interface in the abdomen in background field removal and solving the ill-posed inverse problem. Here we show a method which uses the apparent susceptibility of liver vessels for LIC quantification.

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