Abstract #2861

Quantitative susceptibility mapping including a white matter Lorenzian correction

Diana Khabipova^1,2, Rita Gil², Marcel Zwiers², and José Pedro Marques²

¹CIBM-AIT, EPFL, Lausanne, Switzerland, ²Centre for Cognitive Neuroimaging, Donders Institute, Nijmegen, Netherlands

Quantitative susceptibility mapping (QSM) has been shown to provide quantitative measures of iron concentration in deep gray matter structures. In white matter, QSM is affected not only by local susceptibility but also by the local organized microstructure of axons and its myelin coating where reduced water signal exists. Recently, the anisotropic effect of myelin susceptibility was shown to be minor compared to the effect of its compartmentalization. In this work, the Lorentzian correction was, for the first time, implemented in a COSMOS like QSM reconstruction. The correction does not affect deep gray matter structure values, but creates QSM maps of isotropic susceptibility and maps of the susceptibility of cylindrically organized inclusion spaces.

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