lei hu1, fei yun zha1, dong xing1, wei gong1, jiao wang1, yuan lin1, hui lin2, and xiao xu2
1Renmin Hospital of Wuhan University, wuhan, China, People's Republic of, 2GE healthcare, wuhan, China, People's Republic of
To
estimate the effect of diabetes on vertebral bone marrow, twelve young New
Zealand White rabbits including alloxan-induced diabetic rabbits (n=6) and the controls
(n=6) underwent sagittal magnetic resonance imaging (IDEAL-IQ, DCE-MRI) of
lumbar at each time point. At the week of 16, all rabbits were killed. L7
sampling, HE staining and immunoperoxidase CD31 labeling were performed.
According to statistical analysis, there were statistically significant
differences of the vertebral DCE-MRI parameters and fat fraction (FF) between
the diabetic groups and controls at each time point. The variety of vertebral microvascular
permeability was strongly associated with the increasing vertebral fat
deposition.
