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Abstract #2866

The quantitative research of the vertebral microvascular permeability and fat fraction in alloxan-induced diabetic rabbits

lei hu1, fei yun zha1, dong xing1, wei gong1, jiao wang1, yuan lin1, hui lin2, and xiao xu2

1Renmin Hospital of Wuhan University, wuhan, China, People's Republic of, 2GE healthcare, wuhan, China, People's Republic of

To estimate the effect of diabetes on vertebral bone marrow, twelve young New Zealand White rabbits including alloxan-induced diabetic rabbits (n=6) and the controls (n=6) underwent sagittal magnetic resonance imaging (IDEAL-IQ, DCE-MRI) of lumbar at each time point. At the week of 16, all rabbits were killed. L7 sampling, HE staining and immunoperoxidase CD31 labeling were performed. According to statistical analysis, there were statistically significant differences of the vertebral DCE-MRI parameters and fat fraction (FF) between the diabetic groups and controls at each time point. The variety of vertebral microvascular permeability was strongly associated with the increasing vertebral fat deposition.

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