Abstract #2867

Saturation Recovery Fast Spin Echo Method for Rapid T1 Mapping of Mouse Kidney

Kai Jiang¹, Hui Tang¹, Prassana K. Mishra², Slobodan I. Macura², and Lilach O. Lerman¹

¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, ²Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States

In this study, a saturation recovery fast spin echo method was developed for fast T₁ mapping of mouse kidney at a temporal resolution of ~3 min. The validity of this method was first demonstrated in vitro on a phantom with different concentrations of MnCl₂ by comparing to the conventional spin echo T₁ mapping method and a previously validated saturation recovery Look-Locker (SRLL) method and then in vivo on mouse kidneys at both pre- and post-MnCl₂ infusion by comparing to SRLL.

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