Abstract #2868

SPIO-enhanced MRI as a nondestructive in vivo Method to assess Vascularization of a 3D Matricel Collagen Scaffold planted on the Chorioallantoic Membrane of the Chick Embryo in ovo

Conny F. Waschkies^1,2, Fatma Kivrak Pfiffner³, Yinghua Tian¹, Maurizio Calcagni³, Pietro Giovanoli³, Markus Rudin², and Johanna Buschmann³

¹Division of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland, ²Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland, ³Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland

MRI has been presented as a nondestructive in vivo readout to report perfusion capacity in biomaterials planted on the CAM in the living chick embryo in ovo. Perfusion capacity was assessed through changes in T1 relaxation pre and post injection of a paramagnetic contrast agent, Gd-DOTA (Dotarem®, Guerbet S.A.). Hence local contrast agent concentration was dependent on perfusion, vascular permeability and extravascular compartment size. In the present study we explore intravascular SPIO particles of 30-40 nm size (FeraSpin series M, Viscover™, Miltenyi Biotec, Germany) that stay in the vasculature to deliver a more direct measure of vascularization.

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