Abstract #2869

Influence of Linear and Non-linear Conversions of T1-weighted Signal Intensity to Gadolinium Concentration on Contrast Kinetic Model Parameters: A Simulation Study

Nicole Wake¹, Hersh Chandarana¹, Koji Fujimoto¹, Daniel K Sodickson¹, and Sungheon Gene Kim¹

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University School of Medicine, New York, NY, United States

The purpose of this study was to assess the effect of linear and non-linear signal-to-concentration conversion methods on the estimation of contrast kinetic parameters in T1-weighted dynamic contrast-enhanced MRI. A simulation study was conducted, using the Generalized Kinetic Model with a population-based arterial input function, to compare the two conversion methods in terms of the uncertainty in contrast kinetic parameter estimation, influence by the error in the pre-contrast T1 value, and the effect of flip angle, one of the important scan parameters. The results provide useful information on how to interpret the results with the linear conversion method.

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