Abstract #2870

Measurement of Absolute Cerebral Blood Volume using Velocity-Selective Pulse Trains

Feng Xu^1,2 and Qin Qin^1,2

¹Radiology, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Current MRI techniques for quantification of absolute cerebral blood volume (CBV) are all contrast-based. To reduce associated risks and cost, we proposed a non-contrast-enhanced (NCE) MRI method using a velocity-selective (VS) spin labeling approach for CBV measurement at 3T. Gray matter CBV values across 5 subjects are 2.4±0.2 mL/100g for blood flowing between the encoded cutoff velocities of 0.5cm/s and 3.1cm/s, with a GM/WM ratio of 1.9±0.3.

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