Abstract #2878

Partial Volume Effects Correction for QUASAR ASL: A Spatially Regularised Approach

Moss Y Zhao¹, Egill Rostrup^2,3, Otto Mølby Henriksen³, and Michael A Chappell¹

¹Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ²Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Glostrup, Glostrup, Denmark, ³Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Blegdamsvej, Copenhagen, Denmark

The precise quantification of cerebral blood flow (CBF) using ASL MRI is affected by signal contaminations and partial volume (PV) effects. Among the numerous ASL techniques, QUASAR ASL exhibits unique characteristics of separating tissue and arterial blood components, allowing the bias from the arterial blood component being controlled. However, PV effects remain a critical issue that has not been fully addressed for QUASAR ASL. Here, we investigate a spatially regularised method to correct PV effects in QUASAR ASL using a three-component model. The results indicate that the proposed method preserves more spatial variations than the linear regression method.

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