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Abstract #2880

SCRUB: A Structural Correlation and Empirical Robust Bayesian Method for ASL Data

Sudipto Dolui1,2, David A. Wolk2, and John A. Detre1,2

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

We propose SCRUB, a data cleaning technique to improve cerebral blood flow (CBF) estimation based on arterial spin labeling (ASL) data. The method consists of (i) an outlier detection and removal stage and (ii) a subsequent voxel-wise empirical robust Bayesian estimation step. Compared to alternative options, SCRUB provided (i) better retest agreement between CBF values obtained from ASL scans of elderly Controls in ADNI database acquired 3 months apart, and (ii) better discrimination between Controls and patients with Alzheimer’s disease (AD) based on CBF values in several regions of interest which are sensitive to AD related changes.

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