Abstract #2886

A Correlation Study between DCE-MRI Quantitative Parameters and Immunohistochemical Labeling Indices in Nasopharyngeal Carcinoma

Yunbin Chen ¹, Meng Liu², Dechun Zheng¹, Qiuyuan Yue¹, Xiaoxiao Zhang¹, Hao Lin¹, Weibo Chen ³, Queenie Chan⁴, Wang Ren¹, and Xiangyi Liu¹

¹Fujian Provincial Cancer hospital, Fuzhou, China, People's Republic of, ²Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of, ³Philips Healthcare, Shanghai, China, People's Republic of, ⁴Philips Healthcare, Hong Kong, China, People's Republic of

We assessed correlations between DCE-MRI quantitative parameters with immunohistochemical labeling indices which reflect tumor hypoxia (HIF-1α), tumor angiogenesis (VEGF, MVD) and tumor proliferation (Ki67) in nasopharyngeal carcinoma(NPC). We found that HIF-1α positive group was significantly correlated with VEGF positive expression and MVD count respectively. K^trans and K_epwas positively associated with HIF-1α positive expression, VEGF positive expression and MVD respectively .There were significantly positive correlations between vp and the VEGF expression, MVD count respectively. However, there were no significant relationship between the Ki67 expression and any DCE-MRI quantitative parameters in our study.

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