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Abstract #2886

A Correlation Study between DCE-MRI Quantitative Parameters and Immunohistochemical Labeling Indices in Nasopharyngeal Carcinoma

Yunbin Chen 1, Meng Liu2, Dechun Zheng1, Qiuyuan Yue1, Xiaoxiao Zhang1, Hao Lin1, Weibo Chen 3, Queenie Chan4, Wang Ren1, and Xiangyi Liu1

1Fujian Provincial Cancer hospital, Fuzhou, China, People's Republic of, 2Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of, 3Philips Healthcare, Shanghai, China, People's Republic of, 4Philips Healthcare, Hong Kong, China, People's Republic of

We assessed correlations between DCE-MRI quantitative parameters with immunohistochemical labeling indices which reflect tumor hypoxia (HIF-1α), tumor angiogenesis (VEGF, MVD) and tumor proliferation (Ki67) in nasopharyngeal carcinoma(NPC). We found that HIF-1α positive group was significantly correlated with VEGF positive expression and MVD count respectively. Ktrans and Kepwas positively associated with HIF-1α positive expression, VEGF positive expression and MVD respectively .There were significantly positive correlations between vp and the VEGF expression, MVD count respectively. However, there were no significant relationship between the Ki67 expression and any DCE-MRI quantitative parameters in our study.

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