Abstract #2887

The effect of blood brain barrier disruption on the cerebral blood flow measurement with dynamic susceptibility contrast MRI: Comparison study between SPION and Gd-DOTA

SEOKHA JIN¹ and HyungJoon Cho²

¹UNIST, Ulsan, Korea, Republic of, ²Ulsan, Korea, Republic of

Dynamic susceptibility contrast MRI (DSC MRI) is widely used for cerebral blood flow (CBF) measurement for diseases, such as stroke and cancer.^1-2 Fundamental assumption of DSC-MRI based CBF measurement is that contrast agent is non-leaking with intact blood brain barrier (BBB).³ Here, we investigate the effect of BBB disruption on the CBF measurement, especially for stroke model utilizing serial dual acquisitions using DOTAREM and SPION. As SPION remains as intravascular agent, while DOTAREM becomes extravasating agent with BBB disruption, dual CBF acquisitions with both agents provide quantitative way to characterize the effect of BBB disruption on CBF measurements with DSC-MRI.

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