Abstract #2890

Increasing the inhomogeneous magnetization transfer (ihMT) signal in vivo with high amplitude, low duty cycle irradiation

Gopal Varma¹, Olivier M Girard², Valentin H Prevost², Guillaume Duhamel², and David C Alsop¹

¹Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²CRMBM-CEMEREM UMR 7339, CNRS-AMU, Aix Marseille Université, Marseille, France

High power, off-resonance irradiation as utilized in ihMT/MT can saturate pools of bound magnetization before they exchange in tissues. Observation of such saturation phenomena is limited by power constraints in-vivo and by attenuation of the free pool magnetization. A technique for studying and enhancing saturation effects using relatively short bursts of higher power irradiation is evaluated. The results provided 2-5 fold increases in ihMTR (depending on average power and offset frequency). Such short duration, high power pulses offer a new window to probe exchange kinetics and dipolar order effects, as well as enhancing the quality and feasibility of ihMT imaging.

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