Abstract #2891

On-resonance Variable Delay Multi Pulse Scheme for Imaging of Fast-exchanging Protons and semi-solid Macromolecules

Jiadi Xu^1,2, kannie W. Y. Chan^1,2, Xiang Xu², Nibhay Yadav^1,2, Guanshu Liu^1,2, and Peter C. M. van Zijl^1,2

¹F. M. Kirby Center, Kennedy Kriger Institute, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

An on-resonance variable delay multi-pulse (onVDMP) scheme was developed for separation and quantification of magnetization transfer contrast (MTC) and total fast-exchanging protons (TFP) contributions. Phantom studies of glucose, bovine serum albumin (BSA) and hair conditioner show the capability of onVDMP to separate out exchangeable protons with different exchange rates by their unique signal buildup curves. Quantitative MTC and TFP maps acquired on healthy mouse brains showed strong gray/white matter contrast for the slowly transferring MTC protons while the TFP map was more uniform across the brain.

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