Abstract #2893

Stratification of graded acute stroke metabolic injury with magnetization transfer and relaxation-normalized amide proton transfer (MRAPT) pH-weighted MRI

Phillip Zhe Sun¹, Yingkun Guo^1,2, Iris Yuwen Zhou¹, Suk-Tak Chan¹, Yu Wang³, Emiri Mandeville⁴, Eng H Lo⁴, and Xunming Ji³

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China, People's Republic of, ³Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China, People's Republic of, ⁴Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Amide proton transfer (APT) MRI probes amide protons from endogenous proteins/peptides, which has shown promising results in defining tissue acidosis. pH MRI complements perfusion and diffusion MRI for enhanced stratification of heterogeneous ischemic tissue injury. However, the endogenous APT effect depends not only on pH but also on tissue water content, MRI relaxation rates, and experimental conditions. There are also concomitant RF irradiation effects including direct RF saturation, magnetization transfer and nuclear overhauser effects (NOE). Our study evaluated magnetization transfer and relaxation-normalized APT (MRAPT) MRI in an animal model of acute ischemic stroke that enabled semiautomatic segmentation of graded ischemic tissue injury.

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