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Abstract #2894

CEST-mDixon for Breast Lesion Characterization at 3T

Shu Zhang1, Stephen Seiler1, Ananth Madhuranthakam1,2, Jochen Keupp3, Ivan E Dimitrov2,4, Robert E Lenkinski1,2, and Elena Vinogradov1,2

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Philips Research, Hamburg, Germany, 4Philips Medical Systems, Cleveland, OH, United States

In this work, the feasibility of mDixon-based CEST-MRI for breast lesions characterization at 3T was explored. The mDixon technique was used to acquire pure water CEST images without fat contamination. The B0 maps derived from mDixon technique were used for field inhomogeneity correction. Human studies demonstrated marked differences in MTRasym between malignant and healthy tissue in hydroxyl range (0.8-1.8 ppm) and amide range (3.1-4.1 ppm). In addition, the width of the Z-spectrum was reduced in malignant vs healthy breast tissue. The results suggest that the CEST-mDixon has the potential as a robust detection and characterization tool of breast malignancy.

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