Abstract #2894

CEST-mDixon for Breast Lesion Characterization at 3T

Shu Zhang¹, Stephen Seiler¹, Ananth Madhuranthakam^1,2, Jochen Keupp³, Ivan E Dimitrov^2,4, Robert E Lenkinski^1,2, and Elena Vinogradov^1,2

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ³Philips Research, Hamburg, Germany, ⁴Philips Medical Systems, Cleveland, OH, United States

In this work, the feasibility of mDixon-based CEST-MRI for breast lesions characterization at 3T was explored. The mDixon technique was used to acquire pure water CEST images without fat contamination. The B₀ maps derived from mDixon technique were used for field inhomogeneity correction. Human studies demonstrated marked differences in MTR_asym between malignant and healthy tissue in hydroxyl range (0.8-1.8 ppm) and amide range (3.1-4.1 ppm). In addition, the width of the Z-spectrum was reduced in malignant vs healthy breast tissue. The results suggest that the CEST-mDixon has the potential as a robust detection and characterization tool of breast malignancy.

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