Abstract #2895

Identification of the Origin for Amide Proton Transfer (APT) Imaging Signals in Multiple Pathologies

Dong-Hoon Lee¹, Hye-Young Heo¹, Yi Zhang¹, Shanshan Jiang¹, and Jinyuan Zhou¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

APT imaging can provide endogenous contrast related to the mobile amide proton concentration, amide proton exchange rate (depending on tissue pH), and other tissue and experimental parameters. Here, based on the correlations between quantified APT signals and combined parameter of water proton concentration and water T₁ (T_1w/[water proton]), we attempted to reveal the origin for APT imaging signals in multiple disease models. The results showed no significant correlations between APT signals and the T_1w/[water proton]. Our findings clearly indicated that the APT signals is primarily related to the mobile amide proton concentration and amide proton exchange rate.

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