B0-calibrated and motion-registered dynamic CEST MRI of muscles undergoing exercise
Alessandro M Scotti1,2,3, Rong-Wen Tain1,3, Xiaohong Joe Zhou1,2,3, and Kejia Cai1,3
1Radiology, University of Illinois, Chicago, IL, United States, 2Bioengineering, University of Illinois, Chicago, IL, United States, 3Center for MR Research, University of Illinois, Chicago, IL, United States
Artifacts arising from tissue motion and static field
inhomogeneities can heavily impact the measurement of metabolites concentration
in CEST-MRI experiments in vivo. We present a correction strategy applied to
CEST-MRI of creatine concentration during muscle exercise. Corrections consisted
in image registration by means of a demons algorithm and signal calibration
over static field offsets map at baseline, without the need of additional
scanning. After correction, results are in accord with conventionally corrected
data and published results. This method is shown to be effective in dynamic
studies, where a high temporal resolution and coverage is required.
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