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Abstract #2896

B0-calibrated and motion-registered dynamic CEST MRI of muscles undergoing exercise

Alessandro M Scotti1,2,3, Rong-Wen Tain1,3, Xiaohong Joe Zhou1,2,3, and Kejia Cai1,3

1Radiology, University of Illinois, Chicago, IL, United States, 2Bioengineering, University of Illinois, Chicago, IL, United States, 3Center for MR Research, University of Illinois, Chicago, IL, United States

Artifacts arising from tissue motion and static field inhomogeneities can heavily impact the measurement of metabolites concentration in CEST-MRI experiments in vivo. We present a correction strategy applied to CEST-MRI of creatine concentration during muscle exercise. Corrections consisted in image registration by means of a demons algorithm and signal calibration over static field offsets map at baseline, without the need of additional scanning. After correction, results are in accord with conventionally corrected data and published results. This method is shown to be effective in dynamic studies, where a high temporal resolution and coverage is required.

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