Giuseppe Ferrauto1, Michel Sarraf2, Enza Di Gregorio1, Vincent Auboiroux3, Ulysse Gimenez2, François Berger2, Silvio Aime1, and Hana Lahrech2
1Dept of Molecular Biotechnologies & Health Sciences, University of TORINO (IT), Torino, Italy, 2CLINATEC-CEA-INSERM UA01 – CHU –UJF Grenoble (FR), Grenoble, France, 3CLINATEC-CEA Grenoble (FR), Grenoble, France
MRI maps of
extracellular/extravascular pH distribution in glioblastoma mouse model (U87
cells) have been obtained by administrating YbHPDO3A CEST probe. This molecule
has potential in a clinical setting as it displays analogue properties
(stability and in vivo
pharmacokinetic) of its analogue clinically approved Gd-HPDO3A (ProHance). Furthermore,
glioblastoma pH maps have been correlated with histology
(H/E, Hif-1a and Ki-67 staining). The assessment of glioblastoma pHe could be
used to monitor tumor development and to target acidic tumor regions using
innovative responsive pH therapies.
