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Abstract #2906

Comparison of gagCEST and sodium MRI in evaluating knee cartilage in vivo at 7 Tesla

Vladimir Mlynarik1,2, Stefan Zbyn1, Markus Schreiner3, Vladimir Juras1, Pavol Szomolanyi1, Didier Laurent4, and Siegfried Trattnig1,2

1Department of Biomedical Imaging and Image-Guided Therapy, High Field MR Center, Medical University of Vienna, Vienna, Austria, 2CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Orthopedic Surgery, Medical University of Vienna, Vienna, Austria, 4Novartis Institutes for Biomedical Research, Basel, Switzerland

There are several methodological and data processing issues in gagCEST, which complicate the translation of this method into clinical practice. For assessing performance of the gagCEST protocol optimized in our laboratory, corrected signal intensities from sodium images were used as a reference. The results demonstrate a good correlation between both methods, although the small magnitude of the gagCEST effect and the low resolution in sodium images require carefully optimized methodology and long measurement times. It can be concluded that the gagCEST method can be useful in evaluating early degeneration of articular cartilage at 7 Tesla.

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