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Abstract #2908

Fixed Angle Single Rotation CEST (FASR-CEST) sequence for reducing saturation time

Yi Wang1, Yang Fan2, Bing Wu2, and Jia-Hong Gao1

1School of Physics, Peking University, Beijing, China, People's Republic of, 2MR Research Group, GE Healthcare China, Beijing, China, People's Republic of

In CEST imaging, when saturation time is not sufficient long (empirically smaller than 0.8s), rotation effect would appear and contaminate with saturation effect, making the signal unavailable for further analysis. Considering the inhomogeneity of $$$B_{0}$$$ and $$$B_{1}$$$ in reality, we propose a novel Fixed Angle Single Rotation CEST(FASR-CEST) sequence to overcome the restriction, successfully reducing the saturation time to about 0.5s while keeping identical effect as CEST sequence with long saturation time, with the help of analytical calibration method in another abstract. Effect of the sequence is verified with vitro and in vivo data.

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