Abstract #2909

T1D-w ihMT: Dipolar Relaxation time weighted imaging using inhomogeneous Magnetization Transfer

Guillaume Duhamel¹, Valentin H Prevost¹, Gopal Varma², David C Alsop², and Olivier M Girard¹

¹CRMBM / CNRS 7339, Aix Marseille University, Marseille, France, ²Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

The inclusion of a dipolar reservoir in the existing two pool model for MT allowed interpreting the inhomogeneous MT (ihMT) signal as a dipolar order effect -characterized by a relaxation time T_1D - within motion restricted molecules. In this study, we demonstrate that an ihMT signal can actually be evidenced in any component with non-trivial T_1D value. Adjustment of the dual frequency irradiation efficiency by increase of Δt, the repetition rate of consecutive saturation pulses, filters the signal of shorter T_1D components. This provides a means to realize T_1D-weighted imaging, a new source of MR contrast between tissues.

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