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Abstract #2910

Improvement of in vivo glucoCEST imaging in rat brain using inverse z-spectrum analytical scheme at 7.0 T

Ping-Huei Tsai1,2,3, Hua-Shan Liu4,5, Fei-Ting Hsu6, Yu-Chieh Kao3, Chia-Feng Lu3, Li-Chun Hsieh2, Pen-Yuan Liao2, Hsiao-Wen Chung7, and Cheng-Yu Chen1,2,3

1Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 2Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, 3Translational Imaging Research Center, Taipei Medical University, Taipei, Taiwan, 4Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 5Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, 6Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, 7Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

GlucoCEST have been proposed to assess the discrepant concentrations of glucose in vitro. However, it is still a challenge to obtain accurate signals from glucose in vivo. Our preliminary finding demonstrated that the proposed analytical scheme provides an alternative to extract glucose profile and could be more robust to the field inhomogeneity, which may be helpful in further implementation in disease models.

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