Abstract #2919

Fourier Decomposition MRI using the SENCEFUL Approach for Non-Contrast-Enhanced Ventilation Imaging in Cystic Fibrosis Patients

Simon Veldhoen¹, Andreas Max Weng¹, Clemens Wirth¹, Andreas Steven Kunz¹, Janine Nicole Knapp¹, Daniel Stäb^1,2, Florian Segerer³, Helge Uwe Hebestreit³, Thorsten Alexander Bley¹, and Herbert Köstler¹

¹Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ²The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ³Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany

Fourier Decomposition MRI using the SENCEFUL approach is a recent development in functional lung MRI allowing for site-resolved assessment of lung function. The purpose of the present study is to evaluate its feasibility for ventilation imaging in patients with cystic fibrosis. Seven cystic fibrosis patients and 7 healthy volunteers were examined, lung ventilation maps were reconstructed and quantitative ventilation measurements were performed in tidal and deep breathing. Mean quantitative ventilation was significantly lower for patients with cystic fibrosis when compared to the healthy controls. The ventilation maps indicated increased ventilation inhomogeneity in cystic fibrosis patients.

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