Abstract #2920

Tobacco smoke shortens T1 in a mouse model of COPD

Daniel Alamidi¹, Amir Smailagic², Abdel Bidar², Nicole Parker², Marita Olsson², Sonya Jacksson², Linda Swedin², Paul Hockings^3,4, Kerstin Lagerstrand¹, and Lars E Olsson⁵

¹Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²AstraZeneca R&D, Mölndal, Sweden, ³Medtech West, Chalmers University of Technology, Gothenburg, Sweden, ⁴Antaros Medical, BioVenture Hub, Mölndal, Sweden, ⁵Department of Medical Physics, Lund University, Translational Sciences, Malmö, Sweden

Tobacco smoking is the main cause of COPD. MRI may improve the characterization of COPD where lung T1 mapping has been used to study lung disease. We investigated whether tobacco smoke exposure affects lung T1 in a mouse model with repeated T1 readouts and biological measurements. Free breathing 3D-UTE T1 maps of the lungs were weekly performed over one month in mice exposed to air or tobacco smoke. The lung T1 was shortened in the tobacco smoke exposed mice, most likely due to early signs of smoking-induced lung pathology. Consequently, T1 is a potential biomarker of lung disease.

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