Abstract #2922

Longitudinal Assessment of Pulmonary Permeability in a Mouse Model of Lung Fibrosis

Iliyana P Atanasova¹, Pauline Desogere¹, Clemens K Probst², Nicholas Rotile¹, Andrew M Tager², and Peter Caravan¹

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States

Idiopathic pulmonary fibrosis is a fatal condition without effective treatment. Given evidence that vascular leak promotes fibrosis, we assessed whether pulmonary leak could be quantified using dynamic MRI and an intravascular tracer. In a mouse model we observed that permeability to albumin rose sharply on day 3 after insult, returned to baseline by day 5 and increased moderately between days 5-13. To our knowledge this is the first report of the time course of vascular leak in pulmonary fibrosis. The proposed method could be useful for studying the role of lung permeability in fibrosis and for monitoring of treatment response.

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