Abstract #2924

Pulmonary Fourier decomposition MRI compared to multiple breath washout and spirometry: A preliminary study in Primary Ciliary Dyskinesia

Grzegorz Bauman^1,2, Sylvia Nyilas^2,3,4, Orso Pusterla^1,2, Christoph M Heyer⁵, Cordula Koerner-Rettberg⁶, Philipp Latzin^3,4, and Oliver Bieri^1,2

¹Division of Radiological Physics, Deparment of Radiology, University Hospital of Basel, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³Department of Pediatric Pneumology, University Children's Hospital Basel (UKBB), Basel, Switzerland, ⁴Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Bern, Switzerland, ⁵Institute of Diagnostic Radiology, Interventional Radiology and Nuclear Medicine, Ruhr-University of Bochum, Bochum, Germany, ⁶Department of Pediatric Pneumology, University Children's Hospital of Ruhr University Bochum at St Josef-Hospital, Bochum, Germany

In this work, the feasibility of contrast-media-free pulmonary Fourier decomposition (FD) MRI is assessed in patients with primary ciliary dyskinesia (PCD). An automatic evaluation of regional functional defects on fractional ventilation and perfusion FD maps has been developed. Furthermore, the lung function evaluated using FD MRI is compared to the parameters obtained using multiple breath washout technique and spirometry. Statistical analysis was used to find significant correlations between FD MRI and lung function techniques.

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