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Abstract #2925

Whole Lung Morphometry with Hyperpolarised 3He Gas Diffusion MRI - 3D Multiple b-value Acquisition and Compressed Sensing

Ho-Fung Chan1, Neil J. Stewart1, Juan Parra-Robles1, Guilhem J. Collier1, and Jim M. Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom

Compressed sensing (CS) was implemented to reduce scan time and facilitate acquisition of 3D multiple b-value 3He diffusion-weighted (DW) MRI data for whole lung morphometry. A fully-sampled 3D DW-MRI dataset was retrospectively undersampled using CS simulations to determine optimal k-space undersampling patterns. Whole lung morphometry measurements derived from prospective 3-fold undersampled 3D multiple b-value DW-MRI were compared to 3D and 2D fully-sampled equivalents. Good agreement was obtained between lung morphometry measurements indicating 3D multiple b-value 3He DW-MRI with CS can provide reliable measurements of whole lung morphometry within a single breath-hold.

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