Abstract #2925

Whole Lung Morphometry with Hyperpolarised 3He Gas Diffusion MRI - 3D Multiple b-value Acquisition and Compressed Sensing

Ho-Fung Chan¹, Neil J. Stewart¹, Juan Parra-Robles¹, Guilhem J. Collier¹, and Jim M. Wild¹

¹Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom

Compressed sensing (CS) was implemented to reduce scan time and facilitate acquisition of 3D multiple b-value ³He diffusion-weighted (DW) MRI data for whole lung morphometry. A fully-sampled 3D DW-MRI dataset was retrospectively undersampled using CS simulations to determine optimal k-space undersampling patterns. Whole lung morphometry measurements derived from prospective 3-fold undersampled 3D multiple b-value DW-MRI were compared to 3D and 2D fully-sampled equivalents. Good agreement was obtained between lung morphometry measurements indicating 3D multiple b-value ³He DW-MRI with CS can provide reliable measurements of whole lung morphometry within a single breath-hold.

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