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Abstract #2926

Single breath washout imaging – regional phase III slope mapping with rapid hyperpolarized gas MRI

Felix C Horn 1 and Jim M Wild1

1University of Sheffield, Sheffield, United Kingdom

Single breath washout (SBW) is a whole lung pulmonary function test that has been shown to be sensitive to early changes in lung disease. Of particular clinical interest has been the Phase III slope (SIII) as the concentration decay between 25-75% of the exhaled volume.

In this work rapid lung imaging of exhaled hyperpolarized gas is used to acquire 2D images of SBW of subjects expiring to residual lung volume. The ability to calculate regional SIII from those time resolved images is demonstrated in healthy volunteers.

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