Abstract #2933

Hyperpolarized 129Xe MRI ventilation in pediatric cystic fibrosis lung disease: safety and sensitivity

Laura L Walkup¹, Robert P Thomen^1,2, Teckla Akinyi^1,3, Wolfgang Loew⁴, Kai Ruppert¹, John P Clancy⁵, Zackary I Cleveland¹, and Jason C Woods¹

¹Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Department of Physics, Washington University in St. Louis, St. Louis, MO, United States, ³Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, ⁴Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁵Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

We demonstrate hyperpolarized ¹²⁹Xe MRI in healthy pediatric control subjects and cystic fibrosis patients as young as age 7, for the first time. Subjects experienced a transient nadir in SpO₂ that quickly returns to baseline with normal breathing. Despite having similarly high lung function (i.e., normal FEV₁), CF patients had nearly 4-fold increase in ¹²⁹Xe ventilation defect volume compared to their healthy peers, with statistical significance. Importantly, ventilation defects were present even in CF patients with FEV₁ near or exceeding 100% predicted, suggesting that ¹²⁹Xe MRI is more sensitive to early CF lung disease than traditional clinical spirometry.

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