Abstract #2976

Assessing mucosal inflammation in a DSS-induced colitis mouse model by MR Colonography

Inbal E Biton¹, Noa Stettner¹, Ayelet Erez², Alon Harmelin¹, and Joel R Garbow³

¹Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel, ²Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, ³Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, United States

Inflammatory bowel disease (IBD) is characterized by uncontrolled inflammation of the gastrointestinal tract [1]. Determining the inflammatory state of the colon is critical for defining the disease activity. Endoscopy in human IBD allows visualization of mucosal inflammation [2]. However, the technique is based on grading of the entire colon, which is operator dependent. The mucosa is very fragile, therefore endoscopic evolution is problematic. Therefore, the development of an improved, noninvasive, objective MRI technique may provide a non-invasive assessment tool to depict pathologies in the small intestinal mucosa and, more specifically, along the colon, and to assess the bowel wall and surrounding structures. In this study, dextran sodium sulphate (DSS) polymer treatment was used to induce acute colitis in mice that was subsequently characterized by multi-slice MR colonography.

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