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Abstract #2985

Using frequency difference mapping to assess white matter microstructure in the human corpus callosum

Benjamin Tendler1 and Richard Bowtell1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Frequency difference mapping (FDM) is a recently developed phase-based technique that takes advantage of the non-linear temporal evolution of the phase in GE sequences to produce images that are sensitive to white matter microstructure. Images can be produced simply from raw phase data, with minimal post-processing. In this study 10 subjects underwent six repeats of a single-slice, sagittal multi-echo GE scan on the mid-line. Frequency difference maps reproducibly depicted white matter tracts oriented perpendicular to the applied field. Fitting the FD and magnitude data to a three-pool model provided insight into the variation of microstructure along the corpus callosum.

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