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Abstract #2986

Can myelin protons be directly imaged with the adiabatic inversion recovery prepared ultrashort echo time (IR-UTE) sequence - a validation study based on D2O exchange in sheep brain specimens

Hongda Shao1, Soorena Azam ZAnganeh1, Rong Luo1, Jun Chen1, Graeme Bydder1, and Jiang Du1

1Radiology, University of California, San Diego, San Diego, CA, United States

Directly assessing the integrity of myelin in white matter is important for diagnosis and assessment of prognosis in multiple sclerosis (MS). However, the protons in myelin have extremely short T2s and cannot be directly imaged with conventional clinical MRI sequences. Adiabatic inversion recovery prepared ultrashort echo time (IR-UTE) sequences can detect signal from myelin protons and efficiently suppress the signal from water. In this study we aimed to further validate the IR-UTE technique in sheep brain using a D2O exchange model.

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